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Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

O Saetrum Opgaard1, M Knutsson, R de Vries

  • 1Department of Pharmacology, Erasmus University, 3000 DR Rotterdam, The Netherlands. osaetrum@uci.edu

Clinical Science (London, England : 1979)
|November 29, 2001
PubMed

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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...