Related Experiment Videos
Hyperbaric oxygen therapy for mitomycin C-induced scleral necrosis
1Department of Ophthalmology Gulhane Military Medical Academy and Medical School, Ankara, Turkey.
Ophthalmic Surgery and Lasers
|December 1, 2001
Summary
Topical mitomycin C can cause scleral necrosis after pterygium surgery. Hyperbaric oxygen therapy effectively treated this complication, restoring scleral thickness and function.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Mitomycin C is used to prevent pterygium recurrence after surgery.
- Scleral necrosis is a serious complication associated with mitomycin C use.
Observation:
- A patient developed scleral necrosis 20 days post-pterygiectomy with mitomycin C treatment.
- Conjunctival flap failures occurred after initial treatment.
Findings:
- Hyperbaric oxygen therapy (HBOT) was administered for 24 sessions.
- The patient's sclera revascularized and regained near-normal thickness following HBOT.
Implications:
- This case highlights HBOT as a novel and effective treatment for mitomycin C-induced scleral necrosis.
- Early intervention with HBOT may prevent vision loss from this ophthalmic complication.