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Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
Published on: November 25, 2012
Gene transfer mediated by recombinant baculovirus into mouse eye
F Haeseleer1, Y Imanishi, D A Saperstein
1Department of Ophthalmology, University of Washington, 1959 NE Pacific Street, Box 356-485, Seattle, WA 98195-6485, USA. fanfan@u.washington.edu
Investigative Ophthalmology & Visual Science
|December 1, 2001
Summary
Baculoviruses (BVs) efficiently transfer genes into mouse eye cells, including retinal pigment epithelial cells, after subretinal or intravitreal injection. This gene transfer method shows stable expression and no adverse effects on retinal function.
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