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Updated: Jul 25, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
Hodgkin's lymphoma of T-cell type: clonal association with a CD30+ cutaneous lymphoma
1Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Abstract:
The derivation of Reed-Sternberg cells in Hodgkin's lymphoma has been a subject of great interest. In most cases, Reed-Sternberg cells seem to be derived from germinal center B cells. In few sporadic cases, a T-cell origin has been shown. This article supports the concept of a T-cell derivation for rare cases of Hodgkin's lymphoma and provides evidence of a novel mechanism of pathogenesis from chronic inflammation in the skin.
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