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Related Experiment Videos

Endothelin involvement in respiratory centre activity.

M Albertini1, C L Lafortuna, B Ciminaghi

  • 1Dipartimento di Patologia Animale, Istituto di Tecnologie Biomediche Avanzate del CNR, Milano, Italy. maralbe@mailserver.unimi.it

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|December 1, 2001
PubMed
Summary
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Blocking endothelin (ET) receptors with bosentan improved respiratory mechanics and altered breathing patterns in pigs. This suggests ET plays a role in both the mechanical and neural control of respiration.

Area of Science:

  • Respiratory Physiology
  • Pharmacology

Background:

  • Endothelin (ET) is implicated in cardiovascular regulation.
  • The role of ET in respiratory homeostasis is not fully understood.

Purpose of the Study:

  • To investigate the effects of ET receptor blockade on respiratory mechanics and control.
  • To elucidate the role of ET in maintaining respiratory homeostasis.

Main Methods:

  • Seven anesthetized, spontaneously breathing pigs were administered bosentan (ET(A) and ET(B) receptor antagonist).
  • Respiratory mechanics, diaphragmatic electromyography, and arterial blood gases were monitored for 180 minutes.

Main Results:

  • Bosentan significantly increased respiratory system compliance and decreased resistance.

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  • Tidal volume increased, while respiratory frequency decreased, without altering overall ventilation or blood gas levels.
  • Diaphragmatic activity decreased, and both inspiratory and expiratory times increased, suggesting central respiratory modulation.

    • Conclusions:

    • ET receptor blockade improves respiratory system mechanics in pigs.
    • ET appears to influence both peripheral and central respiratory control mechanisms.
    • ET receptor antagonism demonstrates a significant role for endothelin in respiratory homeostasis.