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Membrane repair: Ca(2+)-elicited lysosomal exocytosis
J V Gerasimenko1, O V Gerasimenko, O H Petersen
1MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK.
Current Biology : CB
|December 1, 2001
Abstract:
Cells in exposed positions are subject to injury and therefore need membrane repair mechanisms. Ca(2+) entry inevitably follows membrane rupture and recent studies indicate that this elicits repair via Ca(2+)-activated exocytosis of lysosomes, regulated by lysosomal synaptotagmin VII.