Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgens: basic biology and clinical implication.

E S Orwoll1

  • 1Bone and Mineral Unit, Oregon Health Sciences University, Portland 97201, USA.

Calcified Tissue International
|December 4, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same author

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Sleep duration and bone health measures in older men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
Same author

Investigation of the Diet-Gut-Muscle Axis in the Osteoporotic Fractures in Men Study.

The journal of nutrition, health & aging·2020
Same author

Rapid suppression of bone formation marker in response to sleep restriction and circadian disruption in men.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same journal

ODAPH (p.Arg77*) Phenotype and Onset of Ameloblast Pathology During Postsecretory Transition Demonstrated by FIB-SEM Analyses of Odaph<sup>C41*/C41*</sup> Mice.

Calcified tissue international·2026
Same journal

Cytokine Networks Reprogramming the Osteo-Immune Microenvironment in Cancer Bone Metastasis.

Calcified tissue international·2026
Same journal

Associations between controlling nutritional status and mortality in osteoporosis: evidence from NHANES, 2005-2018.

Calcified tissue international·2026
Same journal

Gut Microbiota-Derived TMAO Drives MC3T3-E1 Senescence and Osteogenic Dysfunction via cGAS-STING-NF-κB Signaling: Implications for Age-Related Bone Loss.

Calcified tissue international·2026
Same journal

Artificial Intelligence Approaches for Osteoporotic Fracture Risk Prediction Using Administrative Health Data: A Systematic Review.

Calcified tissue international·2026
Same journal

The Important Role of Polycystin in the Skeletal System.

Calcified tissue international·2026
See all related articles

Androgens play a crucial role in bone health, influencing bone remodeling and mass. These hormones are vital for periosteal bone formation and may offer advantages in preventing and treating metabolic bone disorders in both men and women.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Metabolic Bone Disorders

Background:

  • Estrogen's role in bone health is increasingly recognized, potentially overshadowing androgens.
  • Androgens have historically been viewed as essential for male bone biology.
  • Emerging evidence suggests androgens exert independent and significant skeletal actions.

Purpose of the Study:

  • To investigate the independent skeletal actions of androgens.
  • To elucidate the role of androgens in bone cell biology, remodeling, and mass.
  • To explore the clinical implications of androgen effects on bone health and their interaction with estrogen.

Main Methods:

  • Review of recent studies on androgen and estrogen effects on bone.
  • Analysis of non-aromatizable androgens' influence on bone cell biology.

Related Experiment Videos

  • Examination of androgen receptor function and its impact on bone metabolism.

    • Main Results:

    • Non-aromatizable androgens independently modulate bone remodeling and bone mass.
    • Androgens are particularly crucial for periosteal bone formation, potentially explaining gender differences in bone size.
    • Alterations in androgen receptor function impact bone metabolism and receptor homeostasis.

    Conclusions:

    • Androgens have independent skeletal actions crucial for bone health.
    • Bone homeostasis and gender-specific bone characteristics result from combined androgenic and estrogenic actions.
    • Androgens show promise in the prevention and therapy of metabolic bone disorders for both sexes.