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Effect of angiotensin-converting enzyme inhibitor on renal function in ovarian hyperstimulation syndrome in the
M J Teruel1, L F Carbonell, M G Teruel
1Departmento de Fisiología de la Universidad de Murcia, Murcia, Spain.
Objective:
To investigate renal function and whether captopril prevents alterations in the handling of sodium and water in the ovarian hyperstimulation syndrome (OHSS) in the rabbit.
Design:
Experimental study
Setting:
Physiology laboratory.
Animal(S):
Six female New Zealand white rabbits were used as controls, and 13 were hyperstimulated with gonadotropins.
Intervention(S):
Saline or captopril.
Main Outcome Measure(S):
Renal excretory and hemodynamic variables.
Result(S):
The 3% extracellular volume expansion in OHSS animals induced a significant elevation in mean arterial pressure by 27%, although increments in natriuresis and diuresis were similar to those observed in controls. The OHSS group had impaired pressure-natriuresis sensitivity compared with controls (0.36 +/- 0.07 microEq/min/g of Na excreted per mm Hg vs. 1.74 +/- 0.45 microEq/min/g of Na excreted per mm Hg; P<.05. Captopril significantly reduced mean arterial pressure (P<.05) and shifted the pressure-natriuresis response to the left by 0.85 +/- 0.17 microEq/min/g of Na excreted per mm Hg (P<.05).
Conclusion(S):
In OHSS in the rabbit model, pressure-natriuresis sensitivity is impaired. Angiotensin II may play a significant role in this phenomenon, since angiotensin-converting enzyme inhibition normalized the pressure-natriuresis relationship.
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