Parotid and submandibular/sublingual salivary flow during high dose radiotherapy
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Updated: Sep 25, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
Published on: April 24, 2016
F R Burlage1, R P Coppes, H Meertens
1Department of Radiotherapy, University Hospital, P.O. Box 30.0019700 RB, Groningen, The Netherlands.
Abstract:
It was studied whether differences in acute radiosensitivity exist between parotid and submandibular/sublingual glands. The results revealed that salivary flow rates decreased dramatically during the first 2 weeks of radiotherapy. Neither recovery nor significant differences were observed between the production of saliva from the parotid and submandibular/sublingual glands during the 13 weeks observation period.
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