Related Experiment Video
Updated: Oct 3, 2026

Dual Extracellular Recordings in the Mouse Hippocampus and Prefrontal Cortex
Published on: February 16, 2024
Acute intoxication with orphenadrine and clozapine
1Laboratorio di Tossicologia Forense, Istituto di Medicina Legale e delle Assicurazioni, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.
Abstract:
This report describes a fatal intoxication with two different drugs: clozapine and orphenadrine. A 38-year-old man was found dead in the bedroom of his residence. Near the body were found various empty pharmaceutical boxes, employed in schizophrenic therapy, two of them containing clozapine and orphenadrine. High concentrations of clozapine and orphenadrine detected in blood, urine and gastric content were related to death. These compounds were identified and quantitated by liquid-liquid extraction followed by gas chromatographic/mass spectrometry (GC/MS) analysis.
Related Concept Videos
Psychosis: Goals of Pharmacotherapy
Antipsychotic Drugs: Typical and Atypical Agents
Psychosis and Antipsychotic Drugs: Overview
Toxidromes: Clinical Features
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
Phenothiazines, such as prochlorperazine...
Drug Therapy
Antianxiety Medications