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Detection of group C rotavirus in children with acute gastroenteritis in Blantyre, Malawi
N A Cunliffe1, W Dove, B Jiang
1Wellcome Trust Research Laboratory, Department of Paediatrics, University of Malawi College of Medicine Blantyre.
Insights
Group C rotavirus (Gp C RV) was detected in Malawian children with acute gastroenteritis. Most children with Gp C RV were also infected with Group A rotavirus.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Background:
- Acute gastroenteritis is a common childhood illness globally.
- Rotavirus is a leading cause of severe diarrheal disease in children worldwide.
- Group A rotavirus is the most common cause of rotavirus gastroenteritis.
Purpose of the Study:
- To investigate the prevalence of Group C rotavirus (Gp C RV) in children with acute gastroenteritis in Malawi.
- To determine the coinfection rate of Gp C RV with Group A rotavirus.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to detect Gp C RV in fecal specimens.
- The study included 606 children treated for acute gastroenteritis at Queen Elizabeth Central Hospital, Blantyre, Malawi.
Main Results:
- Gp C RV was detected in 3.9% of inpatients (16/408) and 2.0% of outpatients (4/198).
- Of the 13 children excreting Gp C RV, 65% were coinfected with Group A rotavirus.
Conclusions:
- Group C rotavirus is present in children with acute gastroenteritis in Malawi.
- Coinfection with Group A rotavirus is common among children infected with Gp C RV.
Abstract:
Among 606 children who were treated for acute gastroenteritis at the Queen Elizabeth Central Hospital in Blantyre, Malawi, Group C rotavirus (Gp C RV) was detected by enzyme-linked immunosorbent assay in fecal specimens from 16 (3.9%) of 408 inpatients and in 4 (2.0%) of 198 outpatients. Thirteen (65%) children excreting Gp C RV were coinfected with Group A rotavirus.
