Related Experiment Video
Updated: Aug 2, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
Why barium enemas fail to identify colorectal cancers
S McDonald1, P Lyall, L Israel
1Department of Surgery, Christchurch Hospital, Christchurch, New Zealand.
Technical errors most frequently caused missed colorectal cancers during barium enema examinations. Improving barium enema techniques is crucial for accurate cancer detection and patient outcomes.
Area of Science:
- Gastroenterology
- Radiology
- Oncology
Background:
- Colorectal cancer diagnosis relies on imaging techniques like barium enemas.
- Understanding barium enema failure is critical for improving diagnostic accuracy.
Purpose of the Study:
- To identify causes of barium enema failure in detecting colorectal cancers.
- To analyze clinicopathological factors contributing to missed diagnoses.
Main Methods:
- Histopathological data from 1991-1995 were cross-referenced with barium enema records (1990-1995).
- Cases with colorectal cancer diagnosed within 24 months of a negative barium enema were reviewed.
- Radiological reviews attributed failures to technical, interpretive, or perceptive issues.
Main Results:
- Out of 313 patients with colorectal cancer and prior barium enemas, 21 (6.7%) had their cancer missed.
- Technical errors (e.g., poor coating, overlapping loops) were the primary cause of missed diagnoses.
- Double-contrast barium enema (DCBE) was used in 16 of the 21 missed cases.
Conclusions:
- Technical difficulties represent the most common reason for barium enema failure in colorectal cancer detection.
- Missed lesion rates in different bowel regions generally correlate with tumor incidence, with an exception in the cecum.
- Improving barium enema technique is essential to reduce missed colorectal cancer diagnoses.
Related Concept Videos
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Serum Laboratory Studies, Stool Test, Breath Test
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Endoscopic Procedures II: Colonoscopy
Upper GI Series: Barium Swallow
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Lower GI Series: Barium Enema
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...

