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Sulfate-reducing bacteria in relation with other potential periodontal pathogens
P S Langendijk-Genevaux1, W D Grimm, J S van der Hoeven
1Department of Dentistry, University of Nijmegen, Nijmegen, The Netherlands. P.Langendijk@dent.kun.nl
Journal of Clinical Periodontology
|December 12, 2001
Summary
Oral sulfate-reducing bacteria (SRB) correlate with key pathogens in periodontitis. SRB presence is linked to Treponema denticola, Bacteroides forsythus, and Porphyromonas gingivalis, forming a complex associated with destructive disease.
Area of Science:
- Microbiology
- Periodontology
- Oral Health
Background:
- Oral sulfate-reducing bacteria (SRB) are implicated in various periodontitis conditions.
- Understanding the co-occurrence of SRB with other periodontal pathogens is crucial for disease management.
Purpose of the Study:
- To compare the prevalence of SRB with other suspected periodontal pathogens in periodontal lesions.
- To investigate the associations between SRB and specific bacterial species like spirochetes, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Porphyromonas gingivalis, and Treponema denticola.
Main Methods:
- Detection of periodontal SRB using enrichment culture and comparison with spirochete counts (n=168).
- Identification of specific bacterial pathogens (A. actinomycetemcomitans, P. gingivalis, B. forsythus, T. denticola) using 16S rRNA gene-targeted oligonucleotide probes (n=55).
Main Results:
- A significant positive correlation was found between SRB and spirochetes in subgingival plaque.
- SRB showed a negative correlation with A. actinomycetemcomitans.
- SRB were frequently found with T. denticola and/or B. forsythus in periodontal pockets before therapy.
- The combination of SRB and P. gingivalis was observed in 32% of pockets pre-treatment, decreasing significantly post-therapy.
Conclusions:
- SRB presence is positively correlated with T. denticola, B. forsythus, and P. gingivalis in periodontal lesions.
- These bacteria form a complex strongly associated with destructive periodontitis.
- Targeting this bacterial complex may be beneficial in managing periodontitis.