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NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation

N Herring1, L Rigg, D A Terrar

  • 1University Laboratory of Physiology, University of Oxford, Parks Road, OX1 3PT, Oxford, UK.

Cardiovascular Research
|December 12, 2001
PubMed
Summary

The nitric oxide (NO)-cGMP pathway transiently increases heart rate (HR) via the I(f) current during adrenergic stimulation. This effect is limited by phosphodiesterase 2 (PDE2) activity.

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