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Apianane terpenoids from Salvia officinalis
K Miura1, H Kikuzaki, N Nakatani
1Division of Food and Health Science, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi, Osaka 558-8585, Japan.
Phytochemistry
|December 12, 2001
Summary
Three new apianane terpenoids were isolated from Salvia officinalis leaves, alongside 15 known compounds. Structural elucidation was achieved using spectral evidence, expanding knowledge of this plant
Area of Science:
- Phytochemistry
- Natural Products Chemistry
Background:
- Salvia officinalis (common sage) is a medicinal plant with a rich history of traditional use.
- The chemical constituents of Salvia species are known for diverse biological activities.
Purpose of the Study:
- To isolate and characterize novel compounds from Salvia officinalis leaves.
- To identify known constituents present in the plant extract.
Main Methods:
- Phytochemical investigation involving isolation techniques.
- Structure elucidation using comprehensive spectral data analysis (e.g., NMR, MS).
Main Results:
- Three new apianane terpenoids were identified: rel-(5S, 6S, 7S, 10R, 12S, 13R)-7-hydroxyapiana-8,14-diene-11,16-dion-(22,6)-olide, rel-(5S, 6S, 7R, 10R, 12S, 13R)-7-hydroxyapiana-8,14-diene-11,16-dion-(22,6)-olide, and rel-(5S, 6S, 7S, 10R, 12R, 13S)-7-hydroxyapiana-8,14-diene-11,16-dion-(22,6)-olide.
- Fifteen known compounds were also isolated and identified, including salvigenin, lupeol, beta-sitosterol, stigmasterol, physcion, carnosol, rosmadial, rosmanol, epirosmanol, isorosmanol, columbaridione, atuntzensin A, miltirone, carnosic acid, and 12-O-methyl carnosic acid.
Conclusions:
- The study successfully identified novel terpenoids and a range of known compounds from Salvia officinalis.
- The findings contribute to the phytochemical understanding of Salvia officinalis and may inform future research on its medicinal properties.