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New readily accessible peroxides with high anti-malarial potency
Nobutoshi Murakami1, Motoyuki Kawanishi, Sawako Itagaki
1Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871, Osaka, Japan.
Bioorganic & Medicinal Chemistry Letters
|December 12, 2001
Abstract:
In an explorative study for new anti-malarial substances using the methyl esters (1 and 2) of peroxyplakoric acids A(3) and B(3) as scaffolds, 6-carbomethoxymethyl-3-methoxy-3-pentyl-1,2-dioxane, which has been readily synthesized from 6-keto-alpha,beta-unsaturated ester, was found to exhibit potent anti-malarial activity with high selective toxicity.