Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interstrain variation in murine aerobic capacity.

J T Lightfoot1, M J Turner, K A Debate

  • 1Department of Health Promotion and Kinesiology, University of North Carolina-Charlotte, Charlotte, NC 28223, USA. jtlightf@email.uncc.edu

Medicine and Science in Sports and Exercise
|December 12, 2001
PubMed
Summary

Genetic factors significantly influence aerobic capacity in mice. This study quantified maximal aerobic performance across inbred mouse strains, revealing substantial heritability for exercise endurance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The antimicrobial susceptibility patterns of diabetic foot ulcers in the South African public healthcare sector.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

"I must make the grade!": the role of cognitive appraisals, irrational beliefs, exam anxiety, and affect, in the academic self-concept of undergraduate students.

Anxiety, stress, and coping·2024
Same author

When not hitting your sales target is 'the end of the world': Examining the effects of rational emotive behaviour therapy on the irrational beliefs and emotional reactivity of UK-based sales professionals.

Stress and health : journal of the International Society for the Investigation of Stress·2024
Same author

Medical and social needs of pregnant asylum-seekers in Direct Provision.

Irish medical journal·2023
Same author

Implementing Medical Student Teaching on Gynaecological Healthcare of Transgender Patients.

Irish medical journal·2022
Same author

Air Pollution Levels Outside the Capital's Maternity Hospitals.

Irish medical journal·2022

Area of Science:

  • Exercise Physiology
  • Genetics
  • Animal Models

Background:

  • Aerobic capacity is crucial for physical performance and health.
  • The genetic basis underlying variations in aerobic capacity remains largely unexplored.
  • Inbred mouse strains offer a powerful model for dissecting genetic contributions to complex traits.

Purpose of the Study:

  • To investigate the heritability of maximal aerobic performance.
  • To quantify differences in exercise capacity among distinct inbred mouse strains.
  • To establish foundational estimates for the genetic contribution to aerobic fitness.

Main Methods:

  • Maximal aerobic exercise testing was performed on female mice from 10 inbred strains.
  • Mice ran on a treadmill with incrementally increasing speed and grade until exhaustion.

Related Experiment Videos

  • Exercise duration served as the primary measure of maximal aerobic performance.

    • Main Results:

    • Significant inter-strain variability in maximal exercise duration was observed (P < 0.0001).
    • Distinct rankings of exercise duration were identified across the 10 inbred strains.
    • Heritability estimates, including intraclass correlation (0.73) and coefficient of genetic determination (0.58), were significant.

    Conclusions:

    • Aerobic capacity in mice is strongly influenced by genetic factors.
    • These findings highlight the importance of genetics in determining an individual's exercise endurance.
    • Inbred mouse models are valuable for studying the genetic architecture of physiological traits.