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Tyrosine improves appetite, cognition, and exercise tolerance in activity anorexia.

Y Avraham1, S Hao, S Mendelson

  • 1Department of Human Nutrition and Metabolism, Hebrew University-Hadassah Medical School, Jerusalem, Israel 91120.

Medicine and Science in Sports and Exercise
|December 12, 2001
PubMed
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Tyrosine supplementation reversed negative effects of activity-induced anorexia in mice, improving food intake and cognitive function. This suggests tyrosine may help treat eating disorders and enhance exercise performance.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Nutritional Science

Background:

  • The activity wheel model in mice can induce anorexia.
  • Neurochemical changes, including serotonin and dopamine metabolites, are associated with this condition.

Purpose of the Study:

  • To investigate the effects of tyrosine supplementation on exercise tolerance, behavior, and brain neurochemistry in mice using a modified activity wheel model.
  • To explore tyrosine's potential to counteract activity-induced anorexia and its associated neurochemical alterations.

Main Methods:

  • Mice were subjected to a 2-week regimen involving restricted feeding, exercise on a running wheel, and daily injections of either saline or tyrosine.
  • Food consumption, cognitive function (eight-arm maze), and brain neurochemistry (adrenergic and serotonergic metabolites) were assessed.

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Main Results:

  • Activity-induced anorexia led to significant weight loss and decreased food consumption, which tyrosine administration restored.
  • Both physical activity and tyrosine improved cognitive performance in the eight-arm maze.
  • Tyrosine modulated neurochemical changes in the hypothalamus and hippocampus, including those related to serotonin and dopamine.

Conclusions:

  • Tyrosine administration effectively reverses the negative impacts of activity-induced anorexia on food consumption, cognitive behavior, and physical activity.
  • These findings suggest that nutritional interventions with tyrosine may be beneficial for treating eating disorders.
  • Tyrosine may also enhance exercise tolerance and delay fatigue in non-clinical settings.