Related Experiment Video
Updated: Aug 9, 2026

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands
Published on: October 2, 2018
Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors
A S Mikosha1, N D Tron'ko, D V Staren'kii
1V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev. endo@i.kiev.ua
Abstract:
The cytosol and microsomal fractions of human adrenal cortex contain 3 isoforms of protein kinase C: alpha, zeta, and epsilon. The latter fraction is present in trace amounts. No isoforms beta1, beta2, gamma and delta were found in these cell fractions. The distribution of alpha-isoform between the cytosol and microsomal fraction is determined by tissue origin: in normal tissue its content differs by no more than 10%, while in most tumors this isoform is translocated into the microsomal fraction. The distribution of zeta-isoform did not depend on tissue origin.
Related Concept Videos
Cell Specific Gene Expression
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
PI3K/mTOR/AKT Signaling Pathway
cAMP-dependent Protein Kinase Pathways
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology

