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Effects of immune complexes with different molecular weights on functional activity and intracellular pH of

N A Konstantinova1, N F Khomyakova

  • 1Russian State Medical University, Moscow.

Bulletin of Experimental Biology and Medicine
|December 12, 2001
PubMed

Loading of neutrophils with immune complexes changed their functional activity and intracellular pH. These changes depended on the size of immune complexes. UV irradiation of neutrophils loaded with immune complexes led to a molecular weight-dependent decrease in intracellular pH. After irradiation the chemiluminescence response to latex increased only in neutrophils loaded with non-phagocytized immune complexes with low (less than 10 units IgG) and high molecular weights (more than 25 units IgG).

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