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Published on: August 8, 2013
Cryoglobulin composition in patients with myocardial infarction
N A Konstantinova1, I I Yeremin, E V Konstantinova
1N. I. Pirogov Russian State Medical University, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia. katekons@mail.ru
Bulletin of Experimental Biology and Medicine
|January 24, 2012
Summary
This study investigated cryoglobulins in myocardial infarction patients. Elevated cryoglobulin levels and fibronectin complexes were observed, suggesting autoimmune involvement in heart attacks.
Area of Science:
- Immunology
- Cardiology
- Biochemistry
Background:
- Myocardial infarction (MI) involves ischemic damage.
- Autoimmune processes, including cryoglobulins, may accompany MI.
- Cryoglobulins are immunoglobulins with abnormal thermal solubility.
Purpose of the Study:
- To measure serum cryoglobulin and cryocomplex levels in patients with Q-forming myocardial infarction.
- To analyze the composition of cryocomplexes and the presence of fibronectin.
- To correlate cryoprotein dynamics with disease progression.
Main Methods:
- Serum samples from 25 myocardial infarction patients were collected on days 1, 2, 3, 7, and 14.
- Cryoprotein levels were quantified using spectrophotometry.
- Immunoglobulin (IgM, IgA, IgG) and fibronectin concentrations were determined by ELISA.
Main Results:
- Cryoglobulins and their complexes were detected in patients with myocardial infarction.
- Cryocomplexes comprised polyclonal IgG and IgM, occasionally IgA (Type III cryoglobulinemia).
- Fibronectin was present in cryocomplexes, with inverse dynamics to cryocomplex levels.
Conclusions:
- Autoimmune processes, indicated by cryoglobulins, are associated with myocardial infarction.
- Cryocomplexes in MI patients are primarily composed of IgG and IgM.
- Fibronectin's presence and inverse relationship with cryocomplexes warrant further investigation in MI pathogenesis.
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