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Published on: September 9, 2012
Laboratory testing in disseminated intravascular coagulation
1University Department of Haematology, Royal Liverpool University Hospital, Liverpool, United Kingdom. toh@liv.ac.uk
Insights
Current laboratory tests for disseminated intravascular coagulation (DIC) need improvement. New diagnostic approaches focusing on early detection and practicality are essential for better clinical outcomes in DIC.
Area of Science:
- Hematology
- Clinical Pathology
- Critical Care Medicine
Background:
- Clinical prognosis for disseminated intravascular coagulation (DIC) has seen limited improvement.
- Current laboratory testing for DIC may not adequately identify early disease phases.
Purpose of the Study:
- To evaluate available assays for DIC, considering early detection and clinical practicality.
- To propose a framework for improving DIC diagnosis and management.
Main Methods:
- Review and critical analysis of existing laboratory assays for DIC.
- Discussion of the advantages and disadvantages of current diagnostic methods.
Main Results:
- Current DIC testing lacks emphasis on early phase identification.
- Practicality of tests for routine clinical settings is a significant consideration.
Conclusions:
- Advancements in DIC prognosis depend on new or re-analyzed tests for early detection.
- A practical approach to DIC diagnostics is crucial for facilitating therapeutic intervention and clinical trials.
Abstract:
The lack of improvement in the clinical prognosis of disseminated intravascular coagulation (DIC) poses searching questions on the value of current laboratory testing in this area. There is little immediate chance of advancement unless new tests or new modes of analyzing currently available tests place an emphasis on identifying the early phase of DIC. An equal emphasis is also required on practicality to ensure that recommendations are applicable to the routine clinical setting. These two priorities need to be fulfilled to facilitate earlier therapeutic intervention in the clinical trials required for formal assessment of promising and emerging new molecules from successful animal studies. This article therefore discusses the advantages and disadvantages of available assays in DIC with these perspectives in mind. It also proposes a format to bring together the necessary elements required to make an impact on ultimately delivering clinical improvement in this critical area.
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