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Use of FT-NIR transmission spectroscopy for the quantitative analysis of an active ingredient in a translucent
M S Kemper1, E J Magnuson, S R Lowry
1Thermo Nicolet Corporation, Madison, WI 53711, USA. kemper@thermonicolet.com
Abstract:
The objective of this study was to demonstrate the use of transmission Fourier transform near-infrared (FT-NIR) spectroscopy for quantitative analysis of an active ingredient in a translucent gel formulation. Gels were prepared using Carbopol 980 with 0%, 1%, 2%, 4%, 6%, and 8% ketoprofen and analyzed with an FT-NIR spectrophotometer operated in the transmission mode. The correlation coefficient of the calibration was 0.9996, and the root mean squared error of calibration was 0.0775%. The percent relative standard deviation for multiple measurements was 0.10%. The results prove that FT-NIR can be a good alternative to other, more time-consuming means of analysis for these types of formulations.