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Updated: Jul 14, 2026

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

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Injectable fluid silicone therapy. Human morbidity and mortality.

R Ellenbogen, L Rubin

|October 20, 1975

Summary

Silicone injections can cause serious complications, including migration, hypopigmentation, and death. This study highlights silicone as a potential cause of granulomatous hepatitis, a previously undescribed hepatic complication.

Area of Science:

Medical Science
Toxicology
Pathology

Background:

Silicone injections are widely used for cosmetic and reconstructive purposes.
Potential adverse effects of silicone injections are recognized, but hepatic complications are not well-documented.

Observation:

Four patients who received silicone injections presented with severe complications.
Observed complications included silicone migration, hypopigmentation, and fatal outcomes.
One patient developed granulomatous hepatitis, a novel finding linked to silicone.

Findings:

Silicone migration is a known complication, but hepatic involvement was unexpected.
Granulomatous hepatitis, a specific inflammatory liver condition, was identified as a complication.
The study establishes a link between silicone injections and the development of hepatic granulomas.

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Implications:

Silicone should be considered a potential etiological agent for granulomatous hepatitis.
Further research is needed to understand the mechanism of silicone-induced liver disease.
Clinicians should be aware of the risk of severe systemic complications following silicone injections.