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Published on: January 17, 2018
Sepragel sinus (hylan B) as a postsurgical dressing for endoscopic sinus surgery
C P Kimmelman1, D R Edelstein, H J Cheng
1Department of Otolaryngology-Head and Neck Surgery, Manhattan Eye, Ear, and Throat Hospital, 1421 Third Avenue, New York, NY 10021, USA. ckimmelman@aol.com
Summary
Sepragel sinus, a hylan B gel, effectively reduced scarring and stenosis after endoscopic sinus surgery. This gel facilitated healing and offered advantages over traditional stenting materials.
Area of Science:
- Otolaryngology
- Biomaterials Science
Background:
- Endoscopic sinus surgery (ESS) can lead to postoperative complications like scarring and stenosis.
- Effective management of the surgical site is crucial for optimal healing and patient outcomes.
Purpose of the Study:
- To evaluate the safety and efficacy of Sepragel sinus as a postoperative dressing after ESS.
- To assess its role in facilitating healing and preventing scarring and stenosis.
Main Methods:
- A study involving ten patients undergoing bilateral endoscopic ethmoidectomy.
- Sepragel sinus was applied to one ethmoidectomy cavity per patient.
- Outcome measures included synechiae, stenosis, mucosal status, regeneration, and patient-reported pain and congestion.
Main Results:
- Sepragel sinus demonstrated significant improvement in all assessed outcome measures by week 2.
- Statistically significant reductions in synechiae and middle meatal stenosis were observed.
- Early improvements in mucosal healing and reduced postoperative pain were noted.
Conclusions:
- Sepragel sinus serves as an effective space-occupying gel stent, separating sinus mucosal surfaces.
- It shows superiority over no treatment in controlling postethmoidectomy synechiae and stenosis.
- Its biocompatibility and transparency offer advantages over existing stenting materials.
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