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Thrombolysis effect with FIIa from Agkistrodon acutus venom in different thrombosis model
1Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, China.
Aim:
A fibrinolytic enzyme from Agkistrodon acutus venom, called FIIa, was tested for thrombolytic activity in animals.
Methods:
Carotid thrombosis model in rats and rabbits and middle cerebral artery (MCA) thrombosis model in rats were used.
Results:
Intravenous administration of FIIa, at a dosage of 0.625 mg/kg, resulted in thrombolysis of carotid thrombi. However, in middle cerebral artery thrombosis, the effective thrombolysis dose was 1.25 mg/kg. When the dosage of FIIa increased, the thrombolytic effect was stronger. Histological examination of kidney, liver, heart, and lung tissue showed no hemorrhage.
Conclusion:
It shows that FIIa from Agkistrodon acutus venom is able to solubilize thrombus in vivo without hemorrhage at an effective dose for thrombolysis.