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Related Experiment Videos

Dose-dependent behavior of bioactive glass dissolution.

J R Jones1, P Sepulveda, L L Hench

  • 1Centre for Tissue Regeneration, Department of Materials, Imperial College of Science, Technology and Medicine, Prince Consort Road, SW7 2BP, London, United Kingdom.

Journal of Biomedical Materials Research
|December 18, 2001
PubMed
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The concentration of bioactive glass powders influences hydroxycarbonate apatite (HCA) layer formation in simulated body fluid. This finding is crucial for in vitro studies mimicking in vivo conditions.

Area of Science:

  • Biomaterials Science
  • Materials Chemistry

Background:

  • Bioactive glasses are crucial for bone regeneration.
  • Melt-derived 45S5 and sol-gel-derived 58S glasses exhibit distinct textural properties.
  • Understanding dissolution behavior is key to their application.

Purpose of the Study:

  • To investigate the effect of glass dosage on the in vitro dissolution of 45S5 and 58S bioactive glasses.
  • To analyze the formation of hydroxycarbonate apatite (HCA) layers.
  • To correlate dissolution rates with powder concentration in simulated body fluid (SBF).

Main Methods:

  • In vitro dissolution tests of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses in SBF at 37°C.
  • Varying glass dosages from 0.001 to 0.015 g/mL.
  • Elemental analysis (Si, Ca, P, Na) using induced coupled plasma (ICP) analysis.

Related Experiment Videos

  • Surface analysis using Fourier-transform infrared spectroscopy (FTIR).

    • Main Results:

    • Dissolution rates and elemental release varied between melt-derived and sol-gel-derived glasses.
    • The rate of hydroxycarbonate apatite (HCA) layer formation was dependent on the concentration of bioactive glass powders in solution.
    • FTIR confirmed HCA layer formation on reacted glass surfaces.

    Conclusions:

    • Bioactive glass powder concentration significantly impacts in vitro HCA formation.
    • Results necessitate careful consideration of powder concentration in cell-culture studies and extract experiments.
    • Optimizing in vitro conditions is vital for accurate simulation of in vivo bioactive glass performance.