Related Experiment Video
Updated: Sep 8, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Respiratory mechanics in very low birth weight infants during continuous versus intermittent gavage feeds
1Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10461, USA.
Insights
Changing feeding methods for very low birth weight infants from intermittent to continuous enteral feeds did not significantly alter respiratory mechanics. This finding suggests feeding schedules do not impact respiratory system compliance or resistance in stable infants.
Area of Science:
- Neonatal Physiology
- Pediatric Respiratory Medicine
Background:
- Enteral feeding is crucial for very low birth weight infants.
- The method of feeding (intermittent vs. continuous) may influence respiratory function.
Purpose of the Study:
- To investigate the impact of switching from intermittent to continuous enteral feeding on respiratory mechanics in stable, very low birth weight infants.
Main Methods:
- 16 stable infants (<1500g) with no need for respiratory support were studied.
- Respiratory mechanics (compliance, resistance, FRC, tidal volume) were measured before and after feeds.
- Measurements were taken on intermittent feeds and the following day on continuous feeds.
Main Results:
- No significant differences were observed in static respiratory system compliance, resistance, functional residual capacity (FRC), or tidal volume.
- The transition from intermittent to continuous feeding did not affect measured respiratory parameters.
Conclusions:
- Switching enteral feeding from intermittent to continuous schedules does not appear to affect static respiratory mechanics in stable, very low birth weight infants.
- This suggests feeding modality is not a primary determinant of respiratory function in this population.
Abstract:
This study was designed to determine whether respiratory mechanics in stable, very low birth weight infants changed after replacing intermittent feeds with continuous feeding. We measured static respiratory system compliance, respiratory system resistance, functional residual capacity (FRC), and tidal volume immediately before feeds and at 20, 60, and 120 min after feeds, and again the next day on continuous feeds. Patients selected for enrollment into the study needed to fulfill the following criteria: 1) birth weight and postnatal weight < 1,500 g, 2) no need for mechanical ventilation, positive airway pressure, or supplemental oxygen, 3) receiving and tolerating at least 100 mL/kg/day of intermittent gavage feeds, and 4) no change in methylxanthine or diuretic dosage for 3 days before the study. Respiratory mechanics were measured using the SensorMedics 2600 Pediatric Pulmonary Cart (Yorba Linda, CA). We studied 16 infants (gestational age 28.3 +/- 3.7 weeks, mean +/- SD) at a postnatal age of 10-82 days. The average interindividual coefficient of variance was 20 +/- 2% for static compliance, 35 +/- 6% for resistance, 18 +/- 3% for FRC, and 19 +/- 3% for tidal volume. Repeated-measures analysis of variance did not reveal any significant difference in respiratory mechanics with intermittent vs. continuous feeding. The data suggest that static respiratory mechanics in stable, very low birth weight infants are not affected by changing enteral feeds from intermittent gavage to a continuous schedule.
More Related Videos
Related Concept Videos
Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
Pulmonary Cycle: Exhalation
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

