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Updated: Aug 12, 2026
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Two tumors detected by thyroid assessment in two children
1Division of Pediatric Endocrinology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Summary
Early thyroid assessments in children can detect rare tumors. Unusual physical findings and lab results led to the diagnosis of craniopharyngioma and medullary thyroid carcinoma, enabling timely treatment.
Area of Science:
- Pediatric Endocrinology
- Pediatric Oncology
- Diagnostic Imaging
Background:
- Early detection of pediatric tumors is crucial for effective management.
- Thyroid assessments play a key role in identifying various endocrine and neoplastic conditions in children.
Observation:
- A boy with short stature and low free thyroxine (FT4) index, despite normal thyroid-stimulating hormone (TSH), was found to have a craniopharyngioma.
- A girl with a thyroid nodule, upper lip swelling, and rash presented with elevated calcitonin, indicating medullary thyroid carcinoma.
Findings:
- Craniopharyngioma was diagnosed in a boy based on hormonal imbalances and imaging.
- Medullary thyroid carcinoma was confirmed in a girl through elevated calcitonin and genetic testing (RET mutation).
Implications:
- Recognizing subtle clinical and laboratory abnormalities in thyroid evaluations can lead to the early diagnosis of serious pediatric tumors.
- Prompt diagnosis and management of these rare tumors improve patient outcomes and growth.
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