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Antipneumococcal activity of BMS 284756 compared to those of six other agents
Glenn A Pankuch1, Kensuke Nagai, Todd A Davies
1Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
Antimicrobial Agents and Chemotherapy
|December 26, 2001
Abstract:
Antipneumococcal activity of BMS 284756 was compared to those of six agents by MIC and time-kill methodologies. BMS 284756 had the lowest MICs compared to those of ciprofloxacin, levofloxacin, and moxifloxacin against quinolone-susceptible (< or =0.016 to 0.06 microg/ml) and quinolone-resistant (0.03 to 1 microg/ml) pneumococci. BMS 284756 was bactericidal against 11 of 12 strains at two times the MIC after 24 h.