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Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Cell Diversity01:13

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...

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A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics
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A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein Therapeutics

Published on: September 22, 2011

The Celera Discovery System.

Anthony Kerlavage1, Vivien Bonazzi, Matteo di Tommaso

  • 1Celera Genomics, 45 W. Gudd Drive, Rockville, MD 20850, USA. anthony.kerlavage@celera.com

Nucleic Acids Research
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

The Celera Discovery System (CDS) provides researchers with web-based access to extensive genomic and biological data. This comprehensive workbench facilitates data mining and analysis for the scientific community.

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Area of Science:

  • Genomics and Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • The increasing volume of genomic data requires sophisticated tools for effective mining and analysis.
  • Researchers need integrated platforms to access and interpret diverse biological information, including sequence, variation, and expression data.

Purpose of the Study:

  • To introduce the Celera Discovery System (CDS) as a web-accessible research workbench.
  • To highlight the system's capabilities for mining genomic and related biological information.
  • To inform the academic research community about the resources and tools available through CDS.

Main Methods:

  • Web-accessible platform providing access to human and mouse genome sequences with annotations.
  • Integration of over 40 databases covering sequence, mapping, mutation, genetic variation, and expression data.
  • Advanced query capabilities via the LION SRS search engine and a variety of interactive graphical viewers.
  • Inclusion of sequence analysis tools such as similarity searching, pattern searching, multiple sequence alignment, and Hidden Markov Model (HMM) searches.
  • A user workspace for tracking queries and analyses.

Main Results:

  • Users can access and analyze comprehensive human and mouse genomic data, including gene, transcript, and protein information.
  • A wide array of biological data types are available, facilitating multi-faceted research.
  • Advanced search and analysis tools enable efficient data exploration and discovery.

Conclusions:

  • The Celera Discovery System (CDS) serves as a valuable and widely used resource for the academic research community.
  • CDS offers a powerful, integrated environment for genomic data mining and analysis.
  • Subscription access to CDS provides researchers with essential tools for advancing biological discovery.