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euGenes: a eukaryote genome information system.

Donald G Gilbert1

  • 1Center for Genomics and Bioinformatics, Indiana University, Bloomington, IN 47405, USA. gilbertd@bio.indiana.edu

Nucleic Acids Research
|December 26, 2001
PubMed
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euGenes offers a unified eukaryotic genome database for comparative genomics. It integrates diverse gene information, enabling efficient cross-organism analysis for bioscience research.

Area of Science:

  • Bioinformatics
  • Genomics
  • Comparative Genomics

Background:

  • Genome databases are fragmented, hindering cross-organism gene analysis.
  • Bioscientists require integrated resources for understanding gene relationships.

Purpose of the Study:

  • To develop euGenes, a comprehensive eukaryotic genome information system.
  • To provide a unified platform for accessing and analyzing gene data across multiple species.

Main Methods:

  • Automated data extraction and updating from multiple source databases.
  • Standardized gene naming, homology, and functional annotation.
  • Development of integrated whole-genome maps and sequence retrieval options.

Main Results:

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  • euGenes summarizes 150,000+ genes from seven popular eukaryotic genomes (human, mouse, fruit fly, C. elegans, yeast, Arabidopsis, zebrafish).
  • Provides consistent gene names, homologies, and functional/cellular/biological process associations.
  • Offers efficient search capabilities for combined queries on sequence features, protein functions, and gene attributes.

    • Conclusions:

    • euGenes serves as an extensible and flexible genome information system for diverse organisms.
    • Facilitates integration with other projects, such as gene expression databases.
    • Enhances bioscience research through accessible and integrated genomic data.