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5S Ribosomal RNA Database.

Maciej Szymanski1, Miroslawa Z Barciszewska, Volker A Erdmann

  • 1Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Noskowskiego 12, 61704 Poznan, Poland.

Nucleic Acids Research
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

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This study updates the 5S ribosomal RNA (rRNA) database, a crucial component for protein synthesis. The enhanced database includes over 2200 sequences, aiding research in molecular biology and evolution.

Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Ribosomal 5S RNA (5S rRNA) is essential for large ribosomal subunit function in most organisms.
  • It plays a role in stabilizing ribosome structure and enhancing protein synthesis.
  • Previous databases have cataloged 5S rRNA and its genes, but require updates.

Purpose of the Study:

  • To present an updated and comprehensive database of 5S rRNA and 5S ribosomal DNA (rDNA) sequences.
  • To provide a valuable resource for researchers studying ribosomal structure and function.
  • To facilitate comparative genomics and evolutionary studies.

Main Methods:

  • Data compilation from public sequence repositories.
  • Sequence analysis and quality control.

Related Experiment Videos

  • Database curation and web accessibility.

    • Main Results:

    • The updated database contains 2280 primary structures of 5S rRNA and 5S rRNA genes.
    • Sequences are categorized by domain: 536 eubacterial, 61 archaebacterial, 1611 eukaryotic, and 72 organelle.
    • The database is accessible online at http://biobases.ibch.poznan.pl/5SData/.

    Conclusions:

    • The updated 5S rRNA database is a significant resource for the scientific community.
    • It supports research into the structure, function, and evolution of the ribosome.
    • Continued updates will ensure its relevance for ongoing biological research.