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The Histone Database.

Steven Sullivan1, Daniel W Sink, Kenneth L Trout

  • 1Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 45, Room 6AN12J, 45 Center Drive, MSC 6510, Bethesda, MD 20892-6510, USA.

Nucleic Acids Research
|December 26, 2001
PubMed
Summary
This summary is machine-generated.

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The Histone Database offers a comprehensive collection of histone fold-containing sequences, including novel proteins and structural data. This resource aids researchers in exploring histone diversity and function.

Area of Science:

  • Genomics
  • Proteomics
  • Bioinformatics

Background:

  • Histone proteins exhibit high sequence conservation but are a heterogeneous family.
  • Non-histone proteins with the histone fold motif are increasingly recognized.
  • Public databases continuously receive new histone and histone fold protein sequences.

Purpose of the Study:

  • To present a searchable, updated collection of histone fold-containing sequences.
  • To provide access to sequence data, structural information, and histone modifications.
  • To augment taxonomic coverage and facilitate research on histone proteins.

Main Methods:

  • Utilizing sequence-similarity searches of public databases.
  • Compiling and organizing histone fold-containing sequences.

Related Experiment Videos

  • Developing a searchable web-based database with FASTA format sequences.
  • Including partial sequences to expand taxonomic representation.
  • Generating annotated alignments in HTML and PDF formats.

    • Main Results:

    • The Histone Database is a periodically updated, searchable resource.
    • It includes redundant and non-redundant FASTA sequences linked to GenBank.
    • Partial sequences have been added, increasing taxonomic breadth.
    • Annotated alignments of full-length non-redundant sequences are available.
    • Summaries of histone fold structures, modifications, and human gene complements are provided.

    Conclusions:

    • The Histone Database serves as a valuable, integrated resource for histone research.
    • It facilitates the study of histone sequence, structure, and modifications.
    • The database supports ongoing discoveries in genomics and proteomics related to histones.