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InBase: the Intein Database
1New England Biolabs Inc., 32 Tozer Road, Beverly, MA 01915, USA. perler@neb.com
Nucleic Acids Research
|December 26, 2001
Summary
Inteins are protein splicing elements. InBase is a database compiling intein information and providing tools like a BLAST server to help identify new inteins.
Area of Science:
- Biochemistry
- Molecular Biology
- Bioinformatics
Background:
- Inteins are protein sequences that catalyze their own excision and ligation of flanking protein sequences (exteins).
- Protein splicing is a post-translational modification with significant biotechnological applications.
Purpose of the Study:
- To introduce InBase, a comprehensive database and registry for inteins.
- To provide a centralized resource for researchers studying protein splicing.
Main Methods:
- Curated compilation of published and unpublished intein data.
- Development of an intein-specific BLAST server for sequence similarity searches.
Main Results:
- InBase offers general information and detailed data for each intein.
- Includes tabulated comparisons and a comprehensive bibliography.
- The BLAST server facilitates the identification of novel inteins.
Conclusions:
- InBase serves as a valuable resource for the scientific community.
- The availability of an intein-specific BLAST server enhances intein discovery and research.