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Anti-irritative effect of methylrosaniline chloride (Gentian violet)
1Department of Dermatology, Klinikum der Stadt Karlsruhe, Germany. mgloor@onlinehome.de
Background:
There are no published studies of the effect of methylrosaniline chloride (MRC) on inflammation when used at the concentration recommended in the New German Formulary. A tissue-damaging effect has been described in animal studies and at higher concentrations in humans.
Objective:
To determine whether 0.5% MRC increases or reduces skin damage in irritative dermatitis.
Methods:
The study was carried out on the sodium lauryl sulfate (SLS) skin irritation model in 18 healthy volunteers. The impact of intermittent treatment with 0.5% MRC or drug-free vehicle on three SLS exposure effects was determined: reduction of stratum corneum water content (corneometry), increase in subpapillary blood flow (laser Doppler method) and barrier damage (transepidermal water loss).
Results:
MRC produced significant reductions in all three SLS exposure effects.
Conclusions:
Treatment of irritative dermatitis with 0.5% MRC is expected to produce a high clinical efficacy not only because of the compound's established antimicrobial activity, but also because of its anti-irritative effect.
Insights
Methylrosaniline chloride (MRC) at 0.5% significantly reduced skin damage in an irritative dermatitis model. This study suggests MRC possesses anti-irritative effects beneficial for treating skin inflammation.
Area of Science:
- Dermatology
- Pharmacology
Background:
- No studies investigate methylrosaniline chloride (MRC) at New German Formulary concentrations for inflammation.
- Higher concentrations and animal studies suggest MRC may cause tissue damage.
Purpose of the Study:
- To evaluate the effect of 0.5% methylrosaniline chloride (MRC) on skin damage in irritative dermatitis.
Main Methods:
- A sodium lauryl sulfate (SLS) skin irritation model was used in 18 healthy volunteers.
- Intermittent treatment with 0.5% MRC or vehicle was applied.
- Effects on stratum corneum water content (corneometry), subpapillary blood flow (laser Doppler), and transepidermal water loss were measured.
Main Results:
- 0.5% methylrosaniline chloride (MRC) significantly reduced all measured effects of sodium lauryl sulfate (SLS) induced skin irritation.
Conclusions:
- 0.5% methylrosaniline chloride (MRC) demonstrates anti-irritative properties.
- MRC is expected to be highly effective in treating irritative dermatitis, complementing its known antimicrobial activity.