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Remote neurologic manifestations of cancer
1Department of Neurology, Indiana University Medical Center, The Richard Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA. edropcho@iupui.edu
Neurologic Clinics
|January 5, 2002
Abstract:
Paraneoplastic disorders may affect any part of the central or peripheral nervous systems. Although relatively uncommon, these disorders are a significant cause of neurologic morbidity for cancer patients. At least some paraneoplastic syndromes are believed to be caused by an autoimmune reaction against shared tumor-neural antigens. This article summarizes the clinical features of paraneoplastic disorders, the current evidence for autoimmunity, and guidelines for diagnosis and treatment.