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Antimicrobial constituents from the stem bark of Feronia limonia
Md Mukhlesur Rahman1, Alexander I Gray
1Department of Pharmaceutical Sciences, University of Strathclyde, SIBS Building, 27 Taylor Street, G4 ONR, Glasgow, UK.
Abstract:
The stem bark of Feronia limonia (Fam. Rutaceae) yielded (-)-(2S)-5,3'-dihydroxy-4'-methoxy-6",6"-dimethylchromeno-(7,8,2",3")-flavanone along with several known compounds including an alkaloid, five coumarins, a flavanone, a lignan, three sterols and a triterpene. The structures of these compounds were determined by spectroscopic methods, mainly 1D and 2D NMR. The antimicrobial screening of compounds by a microdilution technique resulted in MICs in the range 25-100 microg/ml. Other biological activities of the known compounds are also discussed.
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