Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leptin and reproduction.

Darrell W Brann1, Marlene F Wade, Krishnan M Dhandapani

  • 1Neurobiology Program, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA. dbrann@mail.mcg.edu

Steroids
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MAGEB16 as an epigenetic timing regulator linking X-chromosome biology to neurodevelopmental vulnerability in Autism Spectrum Disorder.

EXCLI journal·2026
Same author

Neuroinflammatory and functional outcomes after TBI are sex-dependent: Lessons from estrous-phase stratified female mice.

Neurochemistry international·2026
Same author

Exploring Sex Differences in Stroke Outcomes: A Comprehensive Analysis From the SPAN 1 Trial.

Journal of the American Heart Association·2026
Same author

Evaluating tocilizumab in ischemic stroke: Findings from the SPAN multicenter trial.

Neuropharmacology·2025
Same author

Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib.

Journal of the American Heart Association·2025
Same author

Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network.

Stroke·2025

Leptin, a hormone cloned in 1994, plays a significant role in reproduction, influencing puberty, pregnancy, and lactation. Research is ongoing to clarify its complex functions and controversies within the reproductive axis.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Molecular Signaling

Background:

  • Leptin, a pleiotropic hormone, has been extensively studied since its 1994 cloning.
  • Over 3000 publications highlight leptin research, indicating its significance.
  • Leptin's broad effects extend to numerous tissues, necessitating a focused review on its reproductive roles.

Purpose of the Study:

  • To review the multifaceted roles of leptin in mammalian reproduction.
  • To explore leptin's influence on gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion.
  • To discuss the reciprocal regulation between leptin, its receptors, and gonadal hormones.

Main Methods:

  • Literature review of studies investigating leptin's reproductive functions.

Related Experiment Videos

  • Analysis of evidence regarding leptin's involvement in puberty, pregnancy, and lactation.
  • Examination of cellular and hypothalamic signaling pathways mediating leptin's effects.

    • Main Results:

    • Accumulating evidence suggests leptin regulates GnRH and LH secretion, puberty onset, pregnancy, and lactation.
    • JAK/STAT, MAPK, and SOCS3 pathways are implicated as cellular mediators of leptin.
    • Cocaine and amphetamine-related transcript (CART) is identified as a hypothalamic mediator, particularly for GnRH control.

    Conclusions:

    • Leptin exerts significant influence on the reproductive axis, though its precise roles remain debated.
    • Reciprocal regulation by gonadal hormones adds complexity to understanding leptin's function.
    • Controversial findings highlight areas for future research into leptin's reproductive endocrinology.