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Novel crosslinking methods to design hydrogels.

W E Hennink1, C F van Nostrum

  • 1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands. w.e.hennink@pharm.uu.nl

Advanced Drug Delivery Reviews
|January 5, 2002
PubMed
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Biodegradable hydrogels are key for controlled drug delivery and cell encapsulation. Physical crosslinking methods offer a safer alternative to chemical methods, avoiding toxic agents and unwanted reactions for improved biocompatibility.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery

Background:

  • Hydrogels are investigated as matrices for controlled release of bioactive molecules and cell encapsulation.
  • Degradation under physiological conditions is crucial for biocompatibility, requiring disintegration into harmless products.

Purpose of the Study:

  • To summarize and discuss chemical and physical crosslinking methods for designing biodegradable hydrogels.
  • To highlight the advantages of physical crosslinking over chemical crosslinking for biomedical applications.

Main Methods:

  • Review of literature on chemical and physical crosslinking techniques for hydrogel synthesis.
  • Comparative analysis of the properties and limitations of each crosslinking approach.

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Main Results:

  • Chemical crosslinking offers versatility and mechanical stability but involves potentially toxic agents.
  • Chemical crosslinking agents can react undesirably with encapsulated bioactive substances.
  • Physical crosslinking avoids toxic agents and adverse reactions, enhancing biocompatibility.

Conclusions:

  • Biodegradable hydrogels are essential for advanced biomedical applications.
  • Physical crosslinking methods present a safer and more biocompatible approach for hydrogel design compared to chemical methods.