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Clinical application of living-related conjunctival-limbal allograft
Kazuo Tsubota1, Shigeto Shimmura, Naoshi Shinozaki
1Department of Ophthalmology, Tokyo Dental College, Ichikawa-shi, Chiba, Japan. tsubota@tdc.ac.jp
Purpose:
To report one successful case of conjunctival-limbal allograft for the treatment of a severe ocular surface disorder.
Methods:
Interventional case report. A 9-year-old patient suffering from Stevens-Johnson syndrome with total keratinization of the ocular surface of both eyes was treated in the left eye by corneal and conjunctival stem cell transplantation. Oral cyclosporin A and topical autologous serum and corticosteroids were administered.
Results:
Mucosal epithelial phenotype was maintained in the left eye at most recent examination for more than 3 years after ocular surface reconstruction.
Conclusion:
A total keratinized ocular surface may be treated with the combination of conjunctival and corneal stem cell transplantation.