Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dedifferentiated liposarcoma.

A G Nascimento1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Seminars in Diagnostic Pathology
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SELNET clinical practice guidelines for bone sarcoma.

Critical reviews in oncology/hematology·2022
Same author

Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature.

Journal of clinical pathology·2009
Same author

Temporal and spatial dynamics of blocking and ripening effects on bacterial transport through a porous system: a possible explanation for CFT deviation.

Colloids and surfaces. B, Biointerfaces·2006
Same author

Low-grade myofibroblastic sarcoma of the parapharyngeal space.

International journal of oral and maxillofacial surgery·2006
Same author

Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas.

Gene therapy·2005
Same author

Primary breast sarcoma: clinicopathologic series from the Mayo Clinic and review of the literature.

British journal of cancer·2004
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Dedifferentiated liposarcoma is a rare, aggressive cancer developing from well-differentiated liposarcoma, primarily affecting older adults in the abdomen. Surgical treatment shows high recurrence and mortality rates.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Genetics

Background:

  • Dedifferentiated liposarcoma is a high-grade nonlipogenic sarcoma.
  • It arises from a preexisting well-differentiated liposarcoma.
  • Primary tumors are more common than secondary ones (9:1 ratio).

Purpose of the Study:

  • To summarize the key characteristics, treatment, and prognosis of dedifferentiated liposarcoma.
  • To highlight the histological and chromosomal features of this sarcoma.
  • To inform clinicians and researchers about this challenging diagnosis.

Main Methods:

  • Review of existing literature on dedifferentiated liposarcoma.
  • Analysis of epidemiological data, including age, sex, and tumor location.
  • Summary of histological findings and chromosomal abnormalities.

Related Experiment Videos

  • Compilation of treatment outcomes, recurrence rates, and mortality data.

    • Main Results:

    • The tumor most frequently affects adults over 60, with a slight male predominance, and commonly occurs in the abdominal cavity.
    • The most frequent histological phenotype is pleomorphic malignant fibrous histiocytoma-like.
    • Surgical treatment is associated with high local recurrence (41-52%), distant metastasis (15%), and disease-related mortality (30%).

    Conclusions:

    • Dedifferentiated liposarcoma is an aggressive malignancy with significant treatment challenges.
    • The characteristic chromosomal abnormality involves the 12q(13-15) region.
    • Further research into novel therapeutic strategies is warranted to improve patient outcomes.