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Pharmacokinetic study of human natural beta-interferon in patients with end-stage renal failure
H Nakayama1, S Shiotani, S Akiyama
1Department of Renal Medicine, Saiyu Soka Hospital, Saitama, Japan. hnakayama@tmch.or.jp
Aims:
Although human natural beta-interferon (beta-IFN) is currently used in the treatment of a number diseases, there have been no published studies of the pharmacokinetics and pharmacodynamics of beta-IFN in patients with end-stage renal failure.
Materials:
Five maintenance hemodialysis patients with chronic hepatitis C (4 men and 1 woman) were enrolled in this study.
Methods:
For the pharmacokinetic study, blood samples were obtained from a forearm vein at intervals, before infusion and 0, 3, 5, 10, 20, 30, and 40 minutes after a 15-minute intravenous infusion of human natural beta-IFN (Feron, Toray Industries, Inc., Tokyo) at a dose of 600 MIU.
Results:
Intravenous beta-IFN was administrated safely to all five patients. The plasma half-life of beta-IFN was found to be 6.91 +/- 2.80 (mean +/- SD) minutes. The initial volume of distribution was found to be 0.49 +/- 0.02 l/kg.
Conclusion:
A 15-minute intravenous infusion of human natural beta-IFN was safely administered to the hemodialysis patients. This pharmacokinetic study showed that it is not necessary to reduce the dosage in patients with end-stage renal failure.