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Pediatric reference ranges for osteocalcin measured by the Immulite analyzer.

H H Seydewitz1, M Henschen, W Kühnel

  • 1Univ-Kinderklinik, Freiburg, Germany. sey@kikli.ukl.uni-freiburg.de

Clinical Chemistry and Laboratory Medicine
|January 5, 2002
PubMed
Summary

This study presents pediatric reference ranges for osteocalcin using a new automated assay. Osteocalcin levels peak during puberty, differing between girls and boys, before declining to adult levels.

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Area of Science:

  • Biochemistry
  • Pediatric Endocrinology

Background:

  • Osteocalcin is a key bone-forming protein.
  • Establishing pediatric reference ranges is crucial for growth assessment.

Purpose of the Study:

  • To establish pediatric reference ranges for osteocalcin.
  • To evaluate a new automated chemiluminescent immunoassay for osteocalcin measurement.

Main Methods:

  • Osteocalcin levels were measured in 627 children (newborns to 18 years).
  • A fully automated, chemiluminescent immunometric assay on the Immulite analyzer was used.

Main Results:

  • Pediatric osteocalcin levels are higher than adult levels.
  • Peak osteocalcin concentrations occur during puberty (approx. 12 years in girls, 14 years in boys).

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  • Levels decline rapidly after puberty towards adult values.

    • Conclusions:

    • The new assay provides reliable osteocalcin measurements in children.
    • Pubertal growth significantly impacts osteocalcin levels in a sex-specific manner.
    • These reference ranges aid in pediatric bone health evaluation.