Additional transporter characterization may lead to new pharmaceutical opportunities

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Xenobiotica; the fate of foreign compounds in biological systems·2008

Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.

AAPS pharmSci·2001

The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.

The journal of peptide research : official journal of the American Peptide Society·1999

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.

The journal of peptide research : official journal of the American Peptide Society·1999

The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.

The journal of peptide research : official journal of the American Peptide Society·1999

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.

Pharmaceutical research·1999

Low Analytical Evaluation Threshold in Leachables Screening: Challenges, Potential Solutions and Alternative Approaches.

Pharmaceutical research·2026

On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D Printing.

Pharmaceutical research·2026

In Vitro-In Vivo Correlation (IVIVC) in Transdermal Drug Delivery Systems: Models, Regulatory Perspectives and Translational Challenges.

Pharmaceutical research·2026

Electrostatic Interactions Guide the Detrimental Effect of Oleic Acid on Monoclonal Antibody Stability.

Pharmaceutical research·2026

Critical evaluation of the impact of ssDNA cargo length on AAV stability - a case study.

Pharmaceutical research·2026

Stimulus-Responsive Polymeric Carriers for Gene Delivery: Balancing Endosomal Escape with Nucleic Acid Release.

Pharmaceutical research·2026

Digestive Hormones and Their Impact on Bariatric and Pharmacologic Weight-Loss Therapies.

Endocrine reviews·2026

Efficacy and safety of TQC3403 in patients with chronic obstructive pulmonary disease (COPD): a multicenter, randomized, open-label, phase 3 equivalence trial.

Journal of thoracic disease·2026

Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions.

Journal of pain research·2026

Smart closed-loop drug delivery systems.

Nature reviews bioengineering·2026

Liposomal Bupivacaine for Postoperative Analgesia After Multilevel Posterior Lumbar Fusion Surgery: A Prospective Three-Arm Randomized Study.

Drug design, development and therapy·2026

Related Experiment Videos

Additional transporter characterization may lead to new pharmaceutical opportunities

Related Concept Videos

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug.

Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts, Caco-2 in vitro cell culture model, and multiple human tissues.

The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.

Synthesis and evaluation of the physicochemical properties of esterase-sensitive cyclic prodrugs of opioid peptides using an (acyloxy)alkoxy linker.

The effect of conformation of the acyloxyalkoxy-based cyclic prodrugs of opioid peptides on their membrane permeability.

Coumarinic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeability.

Low Analytical Evaluation Threshold in Leachables Screening: Challenges, Potential Solutions and Alternative Approaches.

On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D Printing.

In Vitro-In Vivo Correlation (IVIVC) in Transdermal Drug Delivery Systems: Models, Regulatory Perspectives and Translational Challenges.

Electrostatic Interactions Guide the Detrimental Effect of Oleic Acid on Monoclonal Antibody Stability.

Critical evaluation of the impact of ssDNA cargo length on AAV stability - a case study.

Stimulus-Responsive Polymeric Carriers for Gene Delivery: Balancing Endosomal Escape with Nucleic Acid Release.

Digestive Hormones and Their Impact on Bariatric and Pharmacologic Weight-Loss Therapies.

Efficacy and safety of TQC3403 in patients with chronic obstructive pulmonary disease (COPD): a multicenter, randomized, open-label, phase 3 equivalence trial.

Model-Informed Drug Development (MIDD) for Analgesics: Review of Applications, Regulatory Integration, and Emerging Directions.

Smart closed-loop drug delivery systems.

Liposomal Bupivacaine for Postoperative Analgesia After Multilevel Posterior Lumbar Fusion Surgery: A Prospective Three-Arm Randomized Study.

Related Experiment Videos

Additional transporter characterization may lead to new pharmaceutical opportunities

Related Concept Videos

Related Articles