Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-interactive alginate hydrogels for bone tissue engineering.

E Alsberg1, K W Anderson, A Albeiruti

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor 48109-2136, USA.

Journal of Dental Research
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.

Journal of dental research·2026
Same author

Hydrogels in Periodontal and Craniofacial Regeneration: Current Applications and Next-Generation Biomaterials.

Journal of periodontal research·2026
Same author

Anti-inflammatory therapy enables robot-actuated regeneration of aged muscle.

Science robotics·2023
Same author

Tough Adhesive Hydrogel for Intraoral Adhesion and Drug Delivery.

Journal of dental research·2023
Same author

Role of Discoidin Domain Receptor 2 in Craniofacial Bone Regeneration.

Journal of dental research·2021
Same author

The Role of Discoidin Domain Receptor 2 in Tooth Development.

Journal of dental research·2019
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Injectable hydrogel carriers modified with adhesion peptides significantly enhance bone formation by controlling pre-osteoblast cell attachment, proliferation, and differentiation for tissue engineering applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Injectable carriers are crucial for cell transplantation in bone tissue engineering.
  • Controlling cell behavior within these carriers is essential for successful outcomes.

Purpose of the Study:

  • To investigate the impact of covalently coupled adhesion ligands on hydrogel carriers for controlling pre-osteoblast behavior.
  • To evaluate the efficacy of modified alginate hydrogels in promoting in vivo bone formation.

Main Methods:

  • Alginate hydrogels were modified with an RGD-containing peptide (G4RGDY).
  • Osteoblast adhesion, proliferation, and differentiation were assessed in vitro.
  • In vivo bone formation was evaluated after transplantation of primary rat calvarial osteoblasts.

Related Experiment Videos

Main Results:

  • Peptide modification significantly enhanced osteoblast adhesion, proliferation, and differentiation compared to unmodified hydrogels.
  • A minimum adhesion ligand density was required to elicit significant proliferation.
  • Transplantation of modified hydrogels led to statistically significant increases in in vivo bone formation.

Conclusions:

  • Covalently coupling adhesion ligands to hydrogel carriers effectively controls pre-osteoblast behavior.
  • Biomaterial design can be leveraged to guide bone development from transplanted cells.
  • Modified alginate hydrogels show promise for enhancing bone regeneration therapies.