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Deep vein thrombosis in Behçet's disease
M H Houman1, I Ben Ghorbel, I Khiari Ben Salah
1Department of Internal Medicine, Hospital La Rabta, 1007 Tunis, Tunisia. houman.habib@rns.tn
Clinical and Experimental Rheumatology
|January 5, 2002
Summary
Deep vein thrombosis (DVT) affects nearly 40% of Behçet's disease (BD) patients, predominantly males. Male gender and a positive pathergy test are significant risk factors for DVT in BD.
Area of Science:
- Rheumatology
- Vascular Medicine
- Epidemiology
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder.
- Deep vein thrombosis (DVT) is a known complication of BD, but its epidemiological and clinical features require further elucidation.
Purpose of the Study:
- To describe the epidemiological and clinical characteristics of DVT in patients with Behçet's disease.
- To identify risk factors associated with DVT in BD patients.
Main Methods:
- Retrospective study of 113 BD patients classified by international criteria.
- DVT diagnosis confirmed via conventional venous angiography, ultrasonography, and/or CT scans.
- Analysis of clinical and genetic factors, including HLA B51 and MICA 6, comparing patients with and without DVT.
Main Results:
- 38.9% of BD patients (44/113) experienced DVT, with 81 total localizations.
- DVT occurred a mean of 3.8 years after BD onset; in 6 cases, DVT preceded BD diagnosis.
- Significant positive correlations found between DVT and male gender, and a positive pathergy test.
Conclusions:
- DVT occurrence in BD is significantly associated with male gender.
- A positive pathergy test is also a significant risk factor for DVT in Behçet's disease patients.