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Cardiac manifestations of HIV infection in infants and children

M J Keesler1, S D Fisher, S E Lipshultz

  • 1Division of Pediatric Cardiology, University of Rochester Medical Center and Strong Children's Hospital, New York 14642, USA.

Annals of the New York Academy of Sciences
|January 5, 2002
PubMed

Insights

Cardiac issues are common in children with HIV. Left ventricular dysfunction and increased mass are key indicators of survival in these pediatric patients.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Cardiovascular Health

Background:

  • Cardiac manifestations are frequent in pediatric HIV infection.
  • Etiologies, contributing factors, and natural history of these conditions remain understudied.
  • The Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted Human Immunodeficiency Virus Infection Study (P2C2 HIV Study) was established to address this knowledge gap.

Purpose of the Study:

  • To investigate the epidemiology of cardiovascular problems in vertically HIV-infected children.
  • To understand the long-term cardiovascular impact of HIV in pediatric populations.

Main Methods:

  • Longitudinal cohort study design.
  • Data collection initiated in 1989 by the National Heart, Lung and Blood Institute.
  • Focus on vertically transmitted Human Immunodeficiency Virus infection.

Main Results:

  • Cardiovascular problems are common in children with HIV.
  • Left ventricular dysfunction and increased left ventricular mass are frequently observed.
  • These cardiac issues serve as clinically significant indicators of survival.

Conclusions:

  • Cardiovascular complications are prevalent and critical in vertically HIV-infected children.
  • Left ventricular dysfunction and mass are important prognostic markers.
  • Further research is needed to fully elucidate the natural history and management of these conditions.

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