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Updated: Aug 3, 2026

Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats
Published on: February 23, 2015
[Effect of estrous cycle phase on pain threshold in female white rats]
E P Vinogradova1, D A Zhukov, A S Batuev
1I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6, Russia.
Abstract:
Pain thresholds and body resistance in female Wistar rats were determined during estrous cycle stages. The flinch and shuffle thresholds were increased on the 3rd day of measurement in diestrus and estrus but not in proestrus and metestrus as compared with the thresholds during the 1st day of recording. The thresholds decreased as of the 7th day to the 14th day. Daily threshold measurements raised the body resistance on the 7th day of recording. In contrast to the pain thresholds, the body resistance change had not a stage-dependent character.

