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Tissue ingrowth of Replamineform implants.

R T Chiroff, E W White, K N Weber

    Journal of Biomedical Materials Research
    |July 1, 1975
    PubMed
    Summary
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    The Replamineform process creates porous implants that promote bone ingrowth. These materials, including alloys and hydroxyapatite, showed excellent tissue integration without rejection in canine bone.

    Area of Science:

    • Biomaterials Science
    • Orthopedic Surgery
    • Tissue Engineering

    Background:

    • The Replamineform process fabricates porous implant materials mimicking marine invertebrate skeletal structures.
    • This technique offers controlled pore size, microstructure ratio, and pore interconnectivity.

    Purpose of the Study:

    • To evaluate the biocompatibility and bone ingrowth potential of Replamineform-processed materials.
    • To assess tissue response to implants made from chrome-cobalt-molybdenum alloy, alphaA103, hydroxyapatite, and CaCO3.

    Main Methods:

    • Cylindrical implants (1 cm x 0.5 cm) were fabricated using the Replamineform process.
    • Implants were surgically placed into the distal femora and proximal tibiae of adult mongrel dogs.
    • Analysis at 8 weeks included microradiography, scanning electron microscopy, electron microprobe analysis, and histology.

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    Main Results:

    • New bone uniformly grew into the pores of all tested materials and became normally mineralized.
    • No signs of infection, rejection, or encapsulation were observed.
    • Calcium carbonate (CaCO3) implants showed nearly complete resorption within 1 year, replaced by new bone and osteoid.

    Conclusions:

    • Replamineform-processed materials demonstrate excellent biocompatibility and osteoconductivity.
    • The process is suitable for creating porous implants that facilitate bone regeneration.
    • CaCO3 implants exhibit resorbable properties, suggesting potential for temporary bone scaffolds.